Table 3.
Hazard ratio (HR) per quartile increase in each protein, raw p values (p) and false discovery rate (FDR) from univariate cox-regression (left) and multiple regression controlling for age, estimated Glomerular Filtration Rate (eGFR), peakVO2, and left ventricular ejection fraction (LVEF)
| Biomarker | Univariate cox-regression crude analysis | Cox-regression controlled for age, eGFR, peakVO2 and LVEF | ||||
|---|---|---|---|---|---|---|
| HR | p | FDR | HR | p | FDR | |
| Transferrin receptor protein 1 | 2.2 | 0.000 | 0.001 | 2.1 | 0.000 | 0.001 |
| Growth/differentiation factor 15 | 2.1 | 0.000 | 0.002 | 2.0 | 0.001 | 0.004 |
| Galectin-4 | 2.7 | 0.001 | 0.007 | 2.6 | 0.002 | 0.005 |
| Insulin-like growth factor-binding protein 7 | 1.9 | 0.001 | 0.011 | 1.7 | 0.010 | 0.016 |
| ST2 protein | 2.1 | 0.002 | 0.012 | 2.0 | 0.007 | 0.014 |
| Tumor necrosis factor receptor 1 | 2.1 | 0.002 | 0.012 | 1.9 | 0.028 | 0.037 |
| N-terminal prohormone brain natriuretic peptide | 1.4 | 0.004 | 0.014 | 1.3 | 0.054 | 0.062 |
| Tumor necrosis factor receptor 2 | 2.0 | 0.006 | 0.021 | 1.7 | 0.073 | 0.073 |
| Paraoxonase (PON3) | 0.8 | 0.233 | 0.306 | |||
| Tartrate-resistant acid phosphatase type 5 | 0.7 | 0.353 | 0.427 | |||