Table 1.
Overview of liver transplant results in septuagenarians
| References | Year | Study population | Donor type | No. of elderly patients | Selection criteria | Early outcomes | Long-term outcomes |
|---|---|---|---|---|---|---|---|
| Rudich [63] | 1999 | Single center, USA | DDLT | 33 (> 70 yrs) | N/A | Similar complication rates | 1-year OS: 60% |
| Aduen [7] | 2004 | Single center, USA | DDLT | 42 (≥ 70 yrs) | Cardiac stress testing and colonoscopy | Similar complication rates | 1-year graft loss: 17% but 5-year OS: 63% |
| Safdar [64] | 2004 | Single center, USA | DDLT | 33 (≥ 70 yrs) | N/A | No comparison | 1-year OS: 78%; 3-year OS: 71% |
| Lipshutz [6] | 2007 | Single center, USA | DDLT | 62 (≥ 70 yrs) | All patients underwent cardiac workup, regardless of age | Similar complication rates | 1-year 73%; 5-year OS: 47% |
| Schwartz [5] | 2012 | UNOS Registry | DDLT (only 1 LDLT) | 743 (≥ 70 yrs) | N/A | N/A | 1-year actuarial OS: 81%; 5-year actuarial OS: 55% |
| Taner [9] | 2012 | Single center, USA | DDLT | 13 (≥ 75 yrs) | Cardiac stress echo, pulmonary function, nutritional assessment | No comparison | 1-year OS: 100%; 5-year OS: 50% |
| Lai [48] | 2014 | UNOS Registry | DDLT | 343 (≥ 70 yrs) | N/A | No comparison | 1-year graft survival was 56% in patients with MELD ≥ 28 vs. 82% in recipient with lower MELD score |
| Wilson [8] | 2014 | SRTR and UHC databases, USA | DDLT | 323 (≥ 70 yrs) | N/A | Similar complication rates | 1-year OS: 85%; 5-year OS: 64% |
| Oezselik [65] | 2015 | Single center, Turkey | LDLT | 12 (> 70 yrs) | N/A | No comparison | 2 deaths within 6 months post-LT (17%) |
| Kwon [10] | 2017 | Single center, Korea | LDLT–DDLT | 25 (> 70 yrs) | Echocardiography, coronary CT angiography, thallium scan of myocardial perfusion, pulmonary function test, brain MRA | Similar complication rates | 1-year OS: 84%; 5-year OS: 70% |
| Sharma [66] | 2017 | UNOS Registry | DDLT | 1511 (≥ 70 yrs) | N/A | No comparison | 5-year OS about 60% |
| Gil [67] | 2018 | KNHI, Korea | LDLT–DDLT | 84 (> 70 yrs) | N/A | Higher early mortality rates | 20% hospital mortality |
| Mousa [68] | 2019 | Single center, USA | DDLT | 162 (≥ 70 yrs) | N/A | Similar early survival rates | 5-year OS: 71% |
NA Not available, DDLT deceased donor liver transplant, LDLT living donor liver transplantation, USA United States of America, UNOS United Network for Organ Sharing, SRTR Scientific Registry of Transplant Recipients, UHC University Health System Consortium, MRA magnetic resonance angiography, KNHI Korean National Health Insurance, OS overall survival