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. 2020 May 20;37(6):99. doi: 10.1007/s11095-020-02833-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Comparison of fenofibrate loaded LBFs in various models. LBFs were of type IIIA-MC (blue), IIIA-LC (green), and IV (yellow). Normalized AUC values (percentage of the sum of AUC means within each group) for comparison of ranking between groups. “Donor conc.” is the concentration of fenofibrate, either in free solution or in colloidal aggregates within the donor matrix. Values derived from ENA are 10 min of dispersion, followed by 30 or 60 min of digestion in LiDo (this work) and Caco-2 models (19), respectively. Plasma AUC in pigs is derived from 0 to 24 h after administration (14). Abbreviations: medium chain (MC); long chain (LC)