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. 2020 May 20;10:8371. doi: 10.1038/s41598-020-65355-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD103 deficiency exacerbates psoriatic dermatitis. WT mice (n = 5) and Cd103^−/− mice (n = 5) received topical treatment with IMQ on the left ear skin every day for 6 days. (a) Ear thickness was evaluated for 6 days. Data were representative of five individual samples in a single experiment. **P < 0.01 compared with WT mice. (b) Representative pictures of ear skin lesions at 6 days. (c,d) Hematoxylin and eosin (H&E) sections (magnification; 20x) of ear skin at days 0 (None) and 6 (IMQ) (c), and epidermal thickness was evaluated at days 0 (None) and 6 (IMQ) (d). Data were representative of five individual samples in a single experiment. **P < 0.01 compared with WT mice. (e) Immunohistochemical sections (magnification; 20x) for detecting Gr-1 of ear skin at days 0 (None) and 6 (IMQ). (f) The frequency of neutrophils in ear skin at days 0(None) and 6 (IMQ). Data are the mean ± s.d. in four individual samples in a single experiment. **P < 0.01 compared with WT mice. The results are representative of at least three independent experiments with similar results.