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. 2020 May 20;10:8371. doi: 10.1038/s41598-020-65355-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD103 deficiency enhances the activation of cDCs in response to TLR7 ligand. (a) WT mice and Cd103^−/− mice received topical treatment with or without IMQ on the left ear skin every day for 6 days. The expressions of costimulatory molecules on cDCs before and the indicated days after topical application of IMQ. Data are the mean fluorescence intensity (MFI) ± s.d. in three individual samples in a single experiment. *P < 0.05 compared with WT mice. (b,c) cDCs were derived from the skin-draining PLNs in WT mice and Cd103^−/− mice were not stimulated (None) or stimulated with IMQ (IMQ). The transcriptional expressions (b) and the production (c) of cytokines in cDCs. Data are the mean ± s.d. in three individual samples in a single experiment. *P < 0.05, **P < 0.01 compared with WT mice. The results are representative of at least three independent experiments.