. 2020 May 14;9:79–93. doi: 10.2147/ITT.S214139

Table 3.

Differential Diagnosis of CD4 Lymphocytopenia

Infections²⁷^,⁴⁰^,⁴⁹^,⁵³^,⁵⁴^,⁹⁴^,⁹⁸^,¹²⁰	Viral	Adenovirus Parvovirus Influenza Severe acute respiratory distress syndrome Human immunodeficiency virus Human T-cell lymphotropic virus Epstein–Barr virus Cytomegalovirus Hepatitis B Human herpes virus 6 Recalcitrant warts Papillomavirus Measles virus
	Mycobacterial	Mycobacterium tuberculosis Mycobacterium avium intracellulare Atypical mycobacteria
	Fungal	Histoplasmosis Cryptococcosis Coccidioidomycosis
	Bacterial	Rocky mountain spotted fever Brucellosis Sepsis
Autoimmune Disorders⁴⁹^,⁹⁴^,⁹⁸^,¹²⁰	Systemic lupus erythematosus Sjogren’s syndrome Kikuchi disease Rheumatoid arthritis
Malignancies⁴⁹^,⁹⁴^,⁹⁸^,¹²⁰	Lymphoreticular	Lymphoma B cell and T cell
	Hematopoietic	Myelodysplastic syndrome Aplastic anemia
	Others	Mycosis fungoides
Drugs⁹⁴^,⁹⁸^,¹²⁰	Immunosuppressants	Corticosteroids Azathioprine Cyclophosphamide Methotrexate
Drugs⁹⁴^,⁹⁸^,¹²⁰	Chemotherapeutic agents
Genetic/Immune Deficiency Syndromes⁹⁴^,⁹⁶^,⁹⁷^,⁹⁸^,¹¹⁷^,¹²⁰	WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) XMEN (X-linked immunodeficiency with magnesium defect, Epstein–Barr virus infection, and neoplasia) UNC119 mutation MonoMAC syndrome/GATA 2 deficiency Adenosine deaminase deficiency Bare lymphocyte syndrome (type 1) Combined variable immunodeficiency Partial DiGeorge syndrome
Physiological³^,⁹⁴^,⁹⁸^,¹²⁰	Pregnancy, older age, circadian rhythm changes
Others^{49,94,98,120,121}	Sarcoidosis Malnutrition Radiation therapy

Abbreviations: CD4, cluster of differentiation 4; MonoMAC, monocytopenia and mycobacterial infection; GATA, family of transcription factors binding to GATA DNA motif; UNC119, uncoordinated 119 gene.