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. 2020 May 14;14:384. doi: 10.3389/fnins.2020.00384

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Copyright © 2020 Yang, Zheng, Hao, Shi, Lin, Chen, Becvarovski, Pan, Zhang, Hu, Huang, Zheng and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of chronic curdlan supplementation on microgliosis and inflammation in the prefrontal cortex (PFC) and hippocampus of mice fed a HF diet. (A,B) Immunohistochemistry staining of Iba1 in the PFC (A) and the cornus ammonis (CA1), CA2-3, and dentate gyrus (DG) region of hippocampus (B); (C–J) mRNA expression of TNF-α, IL-6, IL-1β, and IL-10 in the PFC (C–F) and hippocampus (G–J). Values are mean ± standard error of means. n = 5. *p < 0.05, **p < 0.01, ***p < 0.001 vs. LF;^#p < 0.05, ^##p < 0.01,^###p < 0.001 vs. HF. Scale bar: 40 μM.