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. 2020 May 14;11:867. doi: 10.3389/fimmu.2020.00867

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Copyright © 2020 Chen, Fuller, Dunlap and Loros.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFN-γ promotes cell survival and proliferation and is not a clock-resetter. (A) Histograms of BMDMs stained with viability dye (zombie red, BioLegend). Gating strategy in Supplemental Figure 3A. (B) Enumeration of the number of events per group in gated flow plots in (A) to determine proliferation. (C) Single, averaged, raw bioluminescence traces of BMDMs treated with IFN-γ (50 ng/mL) or dexamethasone (1 μM) between the times of 12 and 36 h, each sample at every 4 h interval. (D) Circadian wedge diagram depicting time of treatment (magenta dotted line) and time of resultant peaks from each sample group: mock (black circle), IFN-γ (purple triangle), or Dex (orange diamond). Data are represented as mean ± SE (n = 2–3).