Table 4.
Clinical characteristics of patients with R75P mutations.
| Case | Age | Type of mutation | Stroke subtype | Symptoms | Migraine | Cognitive impairment | HTN | DL | DM | Smoking incidence | Family history of stroke | External capsule lesion | Temporal pole lesions | Cerebral microbleeds | Fazekas scale | CADASIL scale | CADASIL scale-J |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 60s | R75P | SVD | Dysarthria, Dysesthesia | − | − | − | + | − | − | + | + | − | + | 2 | 6 | 13 |
| 2 | 40s | R75P | SVD | Cognitive decline | + | + | − | + | − | − | + | + | − | + | 3 | 17 | 20 |
| 3 | 50s | R75P | SVD | Vertigo, Dysarthria, | − | − | + | + | − | − | + | + | − | − | 2 | 7 | 10 |
Exact age is not shown for patient privacy.
HTN, Hypertension; DL, dyslipidemia; DM, diabetes mellitus; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; SVD, small vessel disease.