Table 3.

Serum Biochemical Parameters of SeNPs and Leflunomide Treated Groups in Comparison to Untreated Arthritic Mice (Therapeutic Evaluation)

Groups	ALT (U/L)	ALP (U/L)	TB (mg/dL)	Cr (mg/dL)	Urea (mg/dL)
Healthy (Control)	28.00±9.00	65.00±7.810	0.063±0.005	0.240±0.052	46.330±5.033
RA	37.00±15.556	93.00±0.000*	0.050±0.028	0.240±0.014	46.500±10.606
Leflunomide (10 mg/kg)	18.66±10.263	65.66±18.556	0.470±0.405	0.763±0.098	45.666±20.599
SeNPs (5 mg/kg)	41.00±25.514	52.33±7.505	0.313±0.020	0.710±0.165	47.000±8.660
SeNPs (10 mg/kg)	43.66±1.154	64.00±14.730	0.200±0.052	0.776±0.011	52.333±12.096

Notes: * Significant difference in the level of ALP in the untreated arthritic group (P<0.05) in comparison to the healthy control group.

Abbreviations: ALT, alanine aminotransferase; ALP, alkaline phosphatase; TB, total bilirubin; Cr, creatinine; mg/kg, milligrams per kilogram.