TABLE 5.
miRNA associated clinical trials in urological diseases.
| NCT Number | Status | Study title | Conditions | Type |
| NCT02470507 | Active, not recruiting | Immune Function in Acute Kidney Injury | Acute Kidney Failure | General miRNA profile, observational study |
| NCT02289040 | Completed | Acute Kidney Injury Following Paediatric Cardiac Surgery | Acute Kidney Injury | General miRNA profile, in microvesicles |
| NCT02315183 | Completed | An Observational Case Control Study to Identify the Role of MV and MV Derived Micro-RNA in Post CArdiac Surgery AKI | Acute Kidney Injury | General miRNA profile, observational study |
| NCT03373786 | Completed | A Study of RG-012 in Subjects With Alport Syndrome | Alport Syndrome | miR-21, renal |
| NCT00743054 | Completed | microRNA Expression in Renal Cell Carcinoma | Carcinoma, Renal Cell | General miRNA profile, observational study |
| NCT03227055 | Unknown | Cardiovascular Comorbidity in Children With Chronic Kidney Disease | Childhood Chronic Kidney Disease | urine exosome miRNA |
| NCT01114594 | Completed | Pilot Study of RNA as a Biomarker for Autosomal Dominant Polycystic Kidney Disease | Chronic Kidney Disease Polycystic Kidney, Autosomal Dominant |
General miRNA profile, urine, observational study |
| NCT02147782 | Recruiting | Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency | Chronic Renal Insufficiency Renal Osteodystrophy |
General miRNA profile, observational study |
| NCT02410876 | Recruiting | Changes of microRNA Expression in Obstructive and Neurogenic Bladder Dysfunction | Disorder of the Lower Urinary Tract | General miRNA profile, comparison between BLUTD (bladder outlet obstruction (BOO)-induced) and NLUTD (neurogenic) |
| NCT00806650 | Completed | Anti-IMP3 Autoantibody and MicroRNA Signature Blood Tests in Finding Metastasis in Patients With Localized or Metastatic Kidney Cancer | Kidney Cancer | General, miRNA profile, serum, observational study |
| NCT03089242 | Unknown | MicroRNAs in Acute Kidney Injury | Kidney Injury in Cardiac Surgery - Expression of microRNAs | General miRNA profile |
| NCT01731158 | Unknown | Sequential Therapy With Bevacizumab, RAd001 (Everolimus) and Tyrosinekinase Inhibitors (TKI) in Metastatic Renal Cell Carinoma (mRCC) | Metastatic Renal Cell Carcinoma | General miRNA profile |
| NCT03235128 | Unknown | Clinical Significance of Assesment of Serum miRNA-30a in Childhood Nephrotic Syndrome | Nephrotic Syndrome Steroid-Resistant | miRNA-30a, serum, observational study |
| NCT00565903 | Active, not recruiting | Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome | Cystic Nephroma Pleuropulmonary Blastoma Sertoli-Leydig Cell Tumor of Ovary Medulloepithelioma Embryonal Rhabdomyosarcoma of Cervix Goiter Sarcoma Pineoblastoma Pituitary Tumors Wilms Tumor |
General miRNA profile, observational study |
| NCT01482676 | Completed | The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction | Urinary Bladder Neck Obstruction Cystitis, Interstitial Prostatic Hyperplasia |
General miRNA profile, observational study |
| NCT02316522 | Active, not recruiting | Epigenetic Contribution to the Pathogenesis of Diabetic Nephropathy in Qatari Population | Type 2 Diabetes | General miRNA profile, observational study |
| NCT01973088 | Unknown | Screening and Identification of Human Urate Transporter hURAT1 MicroRNA | Urinary Calculi | miRNAs regulated by hURAT1 |
| NCT03511924 | Completed | Intradialytic Resistance Training in Haemodialysis Patients | Chronic Kidney Disease Requiring Chronic Dialysis | Renal specific miRNA profile |
| NCT03591367 | Completed | The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation | Bladder Cancer; Bladder Disease; Bladder Neoplasm; Micro-RNA | MicroRNAs-155 |
| NCT04176276 | Recruiting | Determining Serum and Urinary Levels of miRNA 192 and miRNA 25 in Patients With and Without Type 2 Diabetes. | Diabetic Kidney Disease; Type2 Diabetes | miR-192 and miR-25 |
| NCT03924089 | Recruiting | Oral Nutritional Supplement on Nutritional and Functional Status, and Biomarkers in Malnourished Hemodialysis Patients. | Malnutrition; End Stage Renal Disease | Circulating miRNAs |
| NCT01829971 | Terminated | A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | Primary Liver Cancer; SCLC; Lymphoma; Melanoma; Multiple Myeloma; Renal Cell Carcinoma; NSCLC | liposomal miR-34a mimic |
| NCT03942744 | Recruiting | The Effect of High-flux Hemodialysis and On-line Hemodiafiltration on Endothelial Function. | Chronic Kidney Disease Requiring Chronic Dialysis | General miRNA profile |
| NCT04300387 | Recruiting | Chronic Kidney Disease at Northeast Taiwan: Biomarker and Multidisciplinary Care | Chronic Kidney Disease | General miRNA profile |
| NCT02593526 | Recruiting | Diuretic/Cool Dialysate Trial | Chronic Kidney Insufficiency | General miRNA profile |
| NCT03202212 | Completed | Effect of Mixed On-line Hemodiafiltration on Circulating Markers of Inflammation and Vascular Dysfunction | Chronic Kidney Failure; Dialysis Related Complication | General miRNA profile in plasmatic exosomes or microvesicles |
| NCT03780101 | Recruiting | Pathology and Imaging in Kidney Allografts | Renal Transplant Rejection; Chronic Kidney Diseases; Fibrosis | miR-214, miR-21 and miR-29 |
| NCT03476460 | Completed | Sodium Chloride and Contrast Nephropathy | Kidney Failure, Chronic; Kidney Failure, Acute; Heart Failure; Diabetes | General miRNA profile |
| NCT03844412 | Suspended | Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments | Vestibulodynia; Temporomandibular Disorder; Fibromyalgia Syndrome; Irritable Bowel Syndrome; Migraines; Tension Headache; Endometriosis; Interstitial Cystitis; Back Pain; Chronic Fatigue Syndrome | General miRNA profile |
| NCT03651388 | Completed | Research Into the Molecular Bases of a New Phenotype Combining Premature White Hair, Polycystic Kidney Disease, Aortic Dilation/Dissection and Lymphopenia | New Phenotype (Combining Premature White Hair, Polycystic Kidney Disease, Aortic Dilation/Dissection and Lymphopenia) | Bcl-2-regulating miRNAs |
| NCT03246191 | Unknown status | Screening and Assessing the Risk Factors and Complications of Chronic Kidney Disease | Chronic Kidney Disease | General miRNA profile, circulating microRNA |
| NCT02691546 | Unknown status | Screening for Chronic Kidney Disease (CKD) Among Older People Across Europe (SCOPE) | Chronic Kidney Diseases | General miRNA profile, circulating microRNA |