Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 14;11:553. doi: 10.3389/fphar.2020.00553

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Wang, Fan, Han, Cai, Wang, Wang and Shang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Gut-derived serotonin (GDS) deficiency ameliorated the progression of non-alcoholic steatohepatitis (NASH). (A) Experimental procedure. (B) The content of 5-hydroxytryptamine (5-HT) positive cell in duodenum of SD rats. (C) The content of 5-HT in serum and duodenum of SD rats. (D) Hematoxylin–eosin (H&E) staining results of each group of rats (evaluated by 6 experts, ×200). (E) Oil red O staining (small red circle) shows hepatic lipid deposits (×200). Hepatic TG concentrations (F) and TC concentrations (G) in SD rats. (H) The CD68 positive cells content (×100). (I) The messenger RNA (mRNA) expression of genes related to the inflammatory response (Tnfα, Il6, Mcp1) in SD rats fed an HFSD diet on days 20 and 30. The terms C20, C30, and M20, etc., are explained in Animals and Treatments. All data are presented as the mean ± SEM (n = 6). ^##P < 0.01, ^###P < 0.001, compared with corresponding control group; ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 compared with relative model group.