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. 2020 May 14;11:694. doi: 10.3389/fphar.2020.00694

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Copyright © 2020 Wang, Wang, Liu, Ma, Huang, Lei, Wen and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resveratrol inhibited glutamate-induced apoptosis of hippocampal neurons by regulating the PI3K/AKT/mTOR pathway. (A) Structural interactions of resveratrol with PI3K (PDB ID: 6AUD) in silico studies. (B) Effects of resveratrol on protein expression of p-PI3K, p-AKT, p-mTOR, Bcl-2, Bax, and Caspase-3 after glutamate-induced apoptosis of hippocampal neurons. ^##P < 0.01 compared with control; ^*P < 0.05 and ^**P < 0.01 compared with glutamate alone; ^&P < 0.05 and ^&&P < 0.01 compared with resveratrol treated.