Figure 8.

Vector Integration Analysis of Bone Marrow of Gene Therapy-Treated Mice

(A) Distribution of the retrieved lentiviral integrations on each chromosome of GAAco-treated mice, 10–12 months after transplantation. (B) The expression of the nearest gene to the vector integration site was assigned a bin from low to high expression. Both integrations of GFP- and GAAco-transduced bone marrow are presented. The vector integrations show the expected lentiviral vector distribution with more frequent integrations in the higher expression bins.