Table 1.
Selection of experimental miRNA studies focusing on biomarker potential in AKI.
| MiRNA | Effect | AKI model | Origin of sample | Reference |
|---|---|---|---|---|
| MiR-16 | Renal function is attenuated in AKI mice by overexpression of miR-16 | Unilateral renal ischemia in mice | Kidney tissue and urine | Chen et al., 2016 |
| MiR-21 | It is upregulated in kidneys after warm ischemia in mice | Unilateral renal ischemia in mice | Kidney tissue | Godwin et al., 2010 |
| Urinary miR-21 is a marker of hypertensive kidney injury in rats | Hypertensive mice with renal tubular lesion | Urine | Chen et al., 2017 | |
| MiR-21 and the miR-17-family are activated after I/R injury in mice | Lethal and sublethal ischemia in mice | Kidney tissue | Kaucsar et al., 2013 | |
| Upregulated in rat kidneys after I/R injury | I/R injury or gentamicin in rats | Plasma and urine | Saikumar et al., 2012 | |
| Mir-30a, and -e, miR-188 | Levels of these miRNAs are upregulated in plasma after contrast induced AKI in rats | Contrast induced AKI in rats | Plasma, kidney tissue | Sun et al., 2016 |
| MiR-34a | In mice, cisplatin treatment induced the expression of miR-34a is induced in renal tissue after cisplatin induced AKI in mice | Cisplatin induced AKI in mice | Kidney tissue | Bhatt et al., 2010 |
| MiR-125b | Significantly increased in rat kidneys after I/R injury | I/R injury in rats | Kidney tissue | Guclu et al., 2017 |
| MiR-140-5p | Upregulated in kidneys. Targets the transcription factor NRF2. | Cisplatin induced AKI in mice | Kidney tissue | Liao et al., 2017a; Liao et al., 2017b |
| MiR-146b | Serum levels of miR-146b increased after cisplatin induced AKI in rats | Cisplatin induced AKI in rats | Serum and kidney tissue | Zhu et al., 2016 |
| MiR-205 | MiR-205 is a marker of ototoxicity in mice treated with aminoglycoside antibiotics | Kanamycin-furosemide stress in mice | Serum | Lee et al., 2018 |
| Let-7d, MiR-203, and -320 | These 3 miRNAs were significantly changed in urine of rats after drug induced AKI | Gentamicin in rats | Urine | Nassirpour et al., 2014 |
| 11 different miRNAs | A set of urinary miRNAs was upregulated in a time dependent manner in male Wistar rats | Cisplatin induced AKI in rats | Urine | Pavkovic et al., 2014 |
I/R, ischemia/reperfusion.