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. 2020 May 14;11:468. doi: 10.3389/fgene.2020.00468

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Copyright © 2020 Avelar-Rivas, Munguía-Figueroa, Juárez-Reyes, Garay, Campos, Shoresh and DeLuna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of gene-drug interactions by competitive-aging screening. (A) Half life of WT-reference samples with (n = 39) or without metformin (n = 40). (B) Scatter plot comparing the CLS phenotypes of 76 gene-deletion strains with or without metformin; the average rescaled relative survivorship rS shown of four replicates is shown. Color scale indicates the p-value of paired t-tests between the S in SC and SC + Metformin. (C) Gene-drug interactions confirmed by live/dead staining. Survival curves of wild-type (light colors) and gene-deletion (dark colors) strains in nominal SC medium (green) or SC + metformin (orange); 95% CI were calculated from at least three replicates (shaded area). The interaction between metformin and gene-deletions was scored significant by two-way ANOVA tests of the death rates (***p < 0.01).