FIGURE 6.

WDFY1 protein levels in pharmacological models of schizophrenia. (A) Immunoblotting for WDFY1 and Tubulin as a loading control in the striatum (Str) and hippocampus (Hipp) of 10-week-old C57BL/6 mice treated with vehicle or amphetamine (3 mg/kg) or ketamine (30 mg/kg) for 8 days (n = 8 vehicle- (Veh), 10 ketamine- (Keta) and 11 amphetamine-treated (Amph) mice). (B) Densitometry quantification of results as in (A). Data were normalized to tubulin for each sample and expressed as percentage of wild type. (C) Immunoblotting for WDFY1 and Tubulin as a loading control in the striatum (Str), frontal cortex (FCtx) and hippocampus (Hipp) of C57BL/6 mice treated at postnatal day 5 with vehicle or LPS (6 mg/kg) or Poly I:C (6 mg/kg) and samples collected 24 h later (n = 9 vehicle- (Veh), 6 LPS- and 7 Poly I:C-treated mice). (D) Densitometry quantification of results as in (C). Data were normalized to tubulin for each sample and expressed as percentage of wild type. Bars represent mean ± SEM. Data were analyzed by one-way ANOVA and the Tukey’s test as a post hoc test in all panels.