Table 1.

Effect of acute treatment with different doses of citicoline on the incidence of tonic seizure and death in intraperitoneal PTZ-induced seizure model.

Groups	Tonic seizure protection (%)	Mortality protection (%)
Solvent	45.5	54.5
Citicoline (125 mg/kg)	50	50
Citicoline (250 mg/kg)	44.4	55.6
Citicoline (500 mg/kg)	50	50

Percentage of protection against incidence of tonic seizures and death subsequent pentylenetetrazole was compared among groups using Fisher's exact test (P > 0.05 for both tonic seizure protection and mortality protection). Each group of mice consisted of eight to ten animals.