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. 2020 May 1;23(5):101114. doi: 10.1016/j.isci.2020.101114

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

DIO Induces Loss of MC4R-HA Specific to PVN in Male and Female MC4R-HA^+/- Mice

(A–C) Confocal microscopy of brain sections derived from male MC4R-HA^+/- mice immunostained with anti-HA. PVN, LFD, n = 8 and HFD, n = 9 (A); LOT, LFD, n = 5, HFD, n = 6 (B); SON, LFD, n = 8, HFD, n = 9 (C).

(D–F) Confocal microscopy of brain sections derived from female MC4R-HA^+/- mice immunostained with anti-HA. PVN, LFD, n = 8, HFD, n = 9 (D); LOT, LFD, n = 5, HFD, n = 6 (E); SON, LFD, n = 7, HFD, n = 9 (F). Data were from 4 MIP per mouse; data in graphs are normalized; scale bar, 80 μm. ^∗∗∗∗, p<0.0001. Data are represented as mean values +/- SD.