Table 2.
BA-Specific Parameters
| Parameter | Process | uCA | uCDCA | uDCA | tCA | tCDCA | tDCA | gCA | gCDCA | gDCA | Dimension | Estimation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ksyn | Synthesis | 27 | 18 | – | – | – | – | – | – | – | umol/h | Taken21,36 |
| ksol | Solubilization | – | – | 0.04 | – | – | – | – | – | – | 1/h | Estimated, pooled data |
| kconj | Conjugation | 4.8 | 4.8 | 4.8 | – | – | – | – | – | – | 1/h | Taken17 |
| ksecLIV | Biliary secretion | – | – | – | 12 | 12 | 12 | 12 | 12 | 12 | 1/h | Taken15 |
| fdcjIL | Scaling factor for tBA and gBA deconjugation | – | – | – | 1 | 1 | 1 | 4 | 4 | 4 | – | Set based on previous estimations17 |
| kdcjCOL | Colonic deconjugation | – | – | – | 5 | 5 | 5 | 5 | 5 | 5 | 1/h | Selected based on sensitivity analysis |
| kdhx | Dehydroxylation | 0.33 | 0.6285 | – | – | – | – | – | – | – | 1/h | Estimated, pooled data |
| kex | Fecal excretion | – | – | 0.07 | – | – | – | – | – | – | 1/h | Calculated from colonic transit time6 |
| kabsUINT | UINT absorption | – | – | – | – | – | – | – | 0.09 | 0.09 | 1/h | Taken15 |
| fabsLINT | Scaling factor for LINT absorption | 2.5 | 3 | 3 | 2.5 | 1 | 1 | 7.5 | 1 | 1 | – | Set based on perfusion studies27 |
| fabsCOL | Scaling factor for COL absorption | 0.02 | 0.2 | 0.13 | – | – | – | – | – | – | – | Set based on perfusion studies28 |
| khupt | Hepatic uptake | 724 | 243 | 190 | 2016 | 848 | 720 | 2016 | 848 | 720 | 1/h | Taken9 |
| fFXR | Scaling factor for | – | 4 | 8 | 5 | 1.7 | 1.7 | 5 | 1.7 | 1.7 | – | Set based on in vitro data29 |
COL, colon; gBA, glycine-conjugated BAs; LINT, lower intestine; tBA, taurine-conjugated BAs; UINT, upper intestine.