Table 1.

Baseline characteristics of patients in the training set

	Total (n = 322)	Severe (n = 26)	Non-severe (n = 296)	p value
Age (years)	51 (36–64)	65 (63–76)	49 (36–63)	< 0.001
Male, n (%)	167 (51.8%)	20 (76.9%)	147 (49.8%)	0.008
Comorbidities, n (%)	107 (33.2%)	18 (69.2%)	89 (30.1%)	< 0.001
WBC (109/L)	4.8 (3.9–6.0)	5.4 (3.6–10.2)	4.8 (4.0–5.9)	0.295
Lymphocyte (109/L)	1.11 (0.79–1.49)	0.65 (0.48–0.87)	1.14 (0.84–1.52)	< 0.001
Platelet (109/L)	179 (143–224)	157 (121–211)	181 (144–226)	0.188
CD3 (cell/μl)	727 (504–1027)	323 (181–542)	773 (550–1054)	< 0.001
CD8 (cell/μl)	250 (159–388)	124 (62–173)	264 (171–404)	< 0.001
CD4 (cell/μl)	428 (299–633)	159 (110–304)	452 (313–650)	< 0.001
CD45 (cell/μl)	1089 (750–1460)	586 (431–799)	1120 (800–1505)	< 0.001
CRP (mg/L)	9 (2–26)	53 (26–87)	8 (2–22)	< 0.001
PCT (ng/mL)	0.03 (0.02–0.06)	0.16 (0.06–0.62)	0.03 (0.02–0.05)	< 0.001
ALT (U/L)	22 (15–34)	26 (19–39)	22 (15–33)	0.067
AST (U/L)	24 (19–33)	45 (26–53)	23 (19–32)	< 0.001
GGT (U/L)	25 (17–42)	28 (21–68)	25 (16–42)	0.119
LDH (U/L)	229 (193–293)	399 (336–499)	224 (192–270)	< 0.001
TBIL (μmol/L)	8.2 (6.6–10.5)	10.3 (8.6–13.8)	8.0 (6.5–10.4)	0.001
BUN (mmol/L)	4.41 (3.55–5.46)	5.10 (4.04–9.80)	4.37 (3.55–5.36)	0.025
Creatinine (μmol/L)	63 (51–76)	80 (57–117)	63 (51–75)	0.002
CK (U/L)	82 (57–130)	220 (113–417)	78 (55–118)	< 0.001
D-dimer (ng/mL)	0.43 (0.29–0.79)	1.20 (0.74–2.23)	0.41 (0.28–0.69)	< 0.001

The p values indicate differences between severe and non-severe patients. p < 0.05 was considered statistically significant

WBC white blood count, CRP C-reactive protein, PCT procalcitonin, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyl-transpeptidase, LDH lactate dehydrogenase, TBIL total bilirubin, BUN blood urea nitrogen, CK creatine kinase