Table 1.
Laboratory Data of Patients with Moderate versus Severe D-Dimer Elevations
| D-Dimer (ng/mL) |
||
|---|---|---|
| ≤3,245 | >3,245 | |
| Standard laboratory | n = 5 | n = 6 |
| CRP (mg/dL) | 4.9 (3.8-26.1) | 27.5 (13.0-32.7) |
| D-dimer (ng/mL) | 2,410 (1,220-2,800) | 15,465 (8,050-19,730) |
| Fibrinogen (mg/dL) | 478 (351-1,057) | 734 (567-1,016) |
| Hematocrit (%) | 28.4 (24.4-30.3) | 25.9 (22.1-28.7) |
| Platelet (× 109/mL) | 211 (152-269) | 144 (104-301) |
| PT (sec) | 14.7 (13-14.7) | 15.1 (14.9-15.4) |
| Thromboelastometry | ||
| EXTEM-CT (s) | 73 (69-74) | 76.5 (73-91.5) |
| EXTEM-A10 (mm) | 63 (60-70) | 67 (61.5-68.9) |
| FIBTEM-A10 (mm) | 30 (30-36) | 36.5 (32.8-43.4) |
| EXTEM-ML (%) | 0 | 0 |
NOTE. Thromboelastometry was performed on the ROTEM Delta (TEM Innovations, Munich, Germany). EXTEM and FIBTEM reagents contain hexadimethrine bromide, that neutralizes heparin. Five patients in the high D-dimer group were on intravenous heparin. Reference ranges: C-reactive protein <1 mg/dL; D-dimer <640 ng/mL fibrinogen equivalent unit; fibrinogen 216-438 mg/dL; hematocrit 37%-50%; platelet 153-367 × 109/mL; prothrombin time 9.6-11.2 sec; EXTEM clotting time 43-82 seconds; EXTEM clot amplitude at 10 minutes 46-67 mm; FIBTEM clot amplitude at 10 minutes 7-24 mm; EXTEM maximal lysis <15%.
Abbreviations: A10, clot amplitude at 10 minutes; CRP, C-reactive protein; CT, clotting time; ML, maximal lysis; PT, prothrombin time.