Table 4.
Hemolytic activities (HC50) and selectivity values (HC50/MIC) obtained for the cationic copolymers P(PEGMA–co–MTZ-BuI) and P(PEGMA–co–MTZ-OcI). HC5, hemolysis percentage below 5%.
| Sample | HC5 (µg/mL) | HC50 (µg/mL) | HC50/MIC | ||||
|---|---|---|---|---|---|---|---|
| S. aureus | S. epidermidis | P. aeruginosa | E. coli | C. parapsilosis | |||
| PEGMA/MTZ-BuI 75/25 | >5000 | >5000 | - | >1 | >1 | - | - |
| PEGMA/MTZ-BuI 50/50 | >5000 | >5000 | >1 | >2 | >1 | - | >1 |
| PEGMA/MTZ-BuI 25/75 | >5000 | >5000 | >1 | >16 | >1 | - | >1 |
| PEGMA/MTZ-BuI 0/100 | 39 | >5000 | >2 | >32 | >8 | >32 | >2 |
| PEGMA/MTZ-OcI 75/25 | 312 | 2500 | 8 | 8 | 1 | 0.5 | 8 |
| PEGMA/MTZ-OcI 50/50 | 19 | 312 | 1 | 4 | <0.12 | <0.06 | 1 |
| PEGMA/MTZ-OcI 25/75 | 2.4 | 39 | <0.25 | 1 | 1 | 0.5 | <0.12 |
| PEGMA/MTZ-OcI 0/100 | <2.4 | 39 | <0.5 | 2 | 1 | 1 | 1 |