Table 6.
Equilibrium solubility (μg/mL) of PG from solid dispersions prepared by co-milling (BM), the corresponding physical mixtures (PM) and neat drug (PG).
Polymer | HPMC | HPMCAS | MCC | PVP | SiO2 |
---|---|---|---|---|---|
BM | 56.68 ± 2.35 | 82.13 ± 4.32 | 14.67 ± 1.31 | 54.42 ± 5.05 | 25.18 ± 0.85 |
PM | 42.52 ± 1.53 | 34.21 ± 1.66 | 15.67 ± 0.80 | 50.90 ± 2.45 | 32.94 ± 0.96 |
PG | 11.49 ± 0.46 |