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. 2020 Mar 26;12(4):736. doi: 10.3390/polym12040736

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Metabolic activity of immature murine articular cartilage (IMAC) cells, as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay 48 h after treatment with (A) increasing concentrations of the PPARδ inhibitor, GSK 3787 and (B) PBSe-GSK3787 and PBSe-NDL particles. No significant toxicity was observed for the free drug or for PBSe-NDL. However, a trend towards higher toxicity was observed for PBSe-GSK3787 particles. Error bars correspond to standard deviations (N = 4).