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. Author manuscript; available in PMC: 2020 Oct 24.
Published in final edited form as: J Med Chem. 2019 Oct 4;62(20):9026–9044. doi: 10.1021/acs.jmedchem.9b00294

Figure 5: Kinetic analysis of gallinamide A inhibition of cathepsin L.

Figure 5:

A. Reaction mechanism and differential equations used to explicitly estimate kinetic constants from product formation curves. B. Representative data for gallinamide A (1) inhibition of cathepsin L. Boxes are experimentally measured progress curves of cathespin L activity with various concentrations of inhibitor, and lines were fit by non-linear regression. Note that I = 0 concentration overlaps with the lowest doses at 0.0169 and 0.0508 nM.