TABLE 4.
Univariate and multivariate Cox regression for overall survival based on different metastatic sites of colorectal cancer
| Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|
| Characteristics | HR (95% CI) | P‐value | HR (95% CI) | P‐value |
| Age at diagnosis | <.001 | <.001 | ||
| <60 | 1 | 1 | ||
| ≥60 | 1.847 (1.806‐1.890) | <.001 | 2.079 (2.031‐2.129) | <.001 |
| Race | <.001 | <.001 | ||
| White | 1 | 1 | ||
| Black | 0.802 (0.774‐0.831) | <.001 | 0.826 (0.797‐0.856) | <.001 |
| Other | 0.712 (0.663‐0.743) | <.001 | 0.701 (0.612‐0.721) | <.001 |
| Gender | <.001 | <.001 | ||
| Female | 1 | 1 | ||
| Male | 1.035 (1.016‐1.055) | <.001 | 1.078 (1.058‐1.099) | <.001 |
| Site | <.001 | <.001 | ||
| Rectum | 1 | 1 | ||
| Left colon | 1.259 (1.243‐1.276) | <.001 | 1.014 (0.983‐1.046) | .380 |
| Right colon | 1.312 (1.266‐1.341) | <.001 | 1.233 (1.196‐1.270) | <.001 |
| CEA | <.001 | <.001 | ||
| Positive | 1 | 1 | ||
| Negative | 0.626 (0.613‐0.640) | <.001 | 0.907 (0.887‐0.928) | <.001 |
| Other | 0.431 (0.420‐0.442) | <.001 | 0.667 (0.650‐0.685) | <.001 |
| Grade | <.001 | <.001 | ||
| I | 1 | 1 | ||
| II | 1.299 (1.249‐1.351) | <.001 | 1.068 (1.027‐1.112) | .001 |
| III | 2.305 (2.209‐2.406) | <.001 | 1.396 (1.335‐1.459) | <.001 |
| IV | 2.738 (2.585‐2.901) | <.001 | 1.551 (1.462‐1.646) | <.001 |
| Histological type | <.001 | <.001 | ||
| AD | 1 | 1 | ||
| MAD | 1.409 (1.365‐1.455) | <.001 | 1.149 (1.113‐1.187) | <.001 |
| SRCC | 2.669 (2.484‐2.867) | <.001 | 1.500 (1.394‐1.615) | <.001 |
| Tumor size | <.001 | <.001 | ||
| <5 | 1 | 1 | ||
| ≥5 | 1.382 (1.356‐1.408) | <.001 | 1.098 (1.076‐1.120) | <.001 |
| LNH | <.001 | <.001 | ||
| <12 | 1 | 1 | ||
| ≥12 | 0.870 (0.851‐0.890) | <.001 | 0.645 (0.629‐0.660) | <.001 |
| T stage | <.001 | <.001 | ||
| T1 | 1 | 1 | ||
| T2 | 1.243 (1.190‐1.299) | <.001 | 1.234 (1.179‐1.290) | <.001 |
| T3 | 2.119 (2.046‐2.193) | <.001 | 1.600 (1.540‐1.661) | <.001 |
| T4 | 4.719 (4.548‐4.897) | <.001 | 2.685 (2.576‐2.800) | <.001 |
| N stage | <.001 | <.001 | ||
| N0 | 1 | 1 | ||
| N1 | 1.671 (1.634‐1.709) | <.001 | 1.327 (1.296‐1.360) | <.001 |
| N2 | 3.278 (3.203‐3.355) | <.001 | 2.059 (2.005‐2.115) | <.001 |
| Liver metastasis | <.001 | <.001 | ||
| No | 1 | 1 | ||
| Yes | 4.347 (4.243‐4.454) | <.001 | 2.589 (2.517‐2.663) | <.001 |
| Lung metastasis | <.001 | <.001 | ||
| No | 1 | 1 | ||
| Yes | 4.384 (4.192‐4.584) | <.001 | 1.618 (1.542‐1.698) | <.001 |
| Bone metastasis | <.001 | <.001 | ||
| No | 1 | 1 | ||
| Yes | 6.461 (5.816‐7.178) | <.001 | 1.761 (1.581‐1.963) | <.001 |
| Brain metastasis | <.001 | <.001 | ||
| No | 1 | 1 | ||
| Yes | 7.120 (5.867‐8.639) | <.001 | 2.460 (2.023‐2.992) | <.001 |
Abbreviations: HR, hazard ratio; CI, confidence interval; CEA, carcinoembryonic antigen; AD, adenocarcinoma; MAD, mucinous adenocarcinoma; SRCC, signet‐ring cell carcinoma; LNH, lymph node harvested.