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. 2020 Apr 29;10(1):182–198. doi: 10.1002/ctm2.21

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© 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The combined application of AQB enhanced the inhibitory effect of palbociclib on wnt/β‐catenin signaling in vitro. A, The Transwell analysis demonstrated that cell invasion was inhibited by U87 and N33 cells alone or in combination (^* P < .05, ^** P < .01, ^*** P < .001, ^**** P < .0001). B, Immunoblot analysis of the effects of small molecule inhibitors on wnt/β‐catenin signaling in glioma cell lines, either alone or in combination. C, The confocal microscopy revealed the changes in the expression of β‐catenin after drug treatment in both cell lines