FIGURE 7.

Potent antitumor efficacy of palbociclib and AQB in tumor‐bearing mice. A, The glioblastoma PDX mice were randomly divided into four groups, and each group was treated with DMSO, AQB (100 mg/kg), palbociclib (100 mg/kg), AQB (100 mg/kg), and palbociclib (100 mg/kg), respectively. Bioluminescence was performed once a week, and the bioluminescence revealed tumor growth. B, The Kaplan‐Meier survival curve revealed the overall survival of tumor‐bearing mice. C, The H&E‐stained images of intracranial tumor tissue sections obtained from nude mice from the different treatment groups. D, The tissue micrographs of the four groups, and the representative micrographs of the immunohistochemistry using antibodies against CWF19L1, CDK4, CDK6, and Ki67 are shown; scale bar, 100 µm. E, The mechanism suggested by the results of the study