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Epigenetic regulation changes in Cav‐1 gene expression. DNA methylation and histone modification are the two major mechanisms of Cav‐1 gene. Epigenetic regulation changes in Cav‐1 gene could act as diagnosis and prognosis biomarkers of various lung diseases. Application of demethylase can reverse the methylation degree changes in promoter region of Cav‐1 gene and induce the re‐expression of Cav‐1. The re‐expression of Cav‐1 makes therapeutic effect on some chronic lung diseases
