Table 9.
Herbal Hand and Foot Bath Plus Chemotherapy: Chemotherapy-Induced Peripheral Neurotoxicity (CIPN).a
| Characteristics (No. of Participants) | CIPN Grades III + IV; Effect Size RR [95% CI] I2 | CIPN All Grades; Effect Size RR [95% CI] I2 | Study ID |
|---|---|---|---|
| FOLFOX4, CRC, first-time chemo after surgery (120) | 0.20 [0.01, 4.08] | 0.59 [0.36, 0.95]b | 11 |
| FOLFOX4, colon cancer, after surgery (44) | 1.00 [0.07, 15.00] | 0.47 [0.26, 0.86]b | 55 |
| Calcium and magnesium + mFOLFOX6, CRC, adjuvant chemotherapy (60) | 0.33 [0.01, 7.87] | 0.83 [0.61, 1.14] | 49.1 |
| mFOLFOX6, CRC, adjuvant chemotherapy (60) | 0.20 [0.01, 4.00] | 0.96 [0.76, 1.22] | 49.2 |
| mFOLFOX6, colon cancer, after surgery (40) | 0.33 [0.04, 2.94] | 0.47 [0.24, 0.89]b | 9 |
| XELOX, CRC, first time received oxaliplatin treatment (50) | 0.25 [0.03, 2.08] | 0.40 [0.19, 0.86]b | 2 |
| Total pool, 5 RCTs, 6 comparisons (374) | 0.35 [0.10, 1.20] 0% | 0.69 [0.50, 0.95]b 68.8% | All above |
| Sensitivity 1, 5 RCTs, 5 comparisons (314)c | 0.32 [0.11, 0.99]b 0% | 0.58 [0.37, 0.91]b 75% | 2, 9, 11, 49.2, 55 |
| Sensitivity 2, 4 RCTs, 4 comparisons (254)d | 0.35 [0.10, 1.17] 0% | 0.50 [0.37, 0.67]b 0% | 2, 9, 11, 55 |
Abbreviations: CI, confidence interval; RR, relative risk; RCT, randomized controlled trial.
a
All studies used herbal hand and foot baths combined with chemotherapy versus the same chemotherapy.
b
Statistically significant.
c
Sensitivity 1 excluded Study No. 49 group T1 to remove double counting due to this study having 2 comparisons.
d
Sensitivity 2 excluded Study No. 49 altogether (groups T1 and T2).