Table 3.
Distribution of hr-HPV genotypes and histological results among hr-HPV-positive/cytology-negative women
| HPV Type(s) | Histological Results | ||||||
|---|---|---|---|---|---|---|---|
| TOTAL | NORMAL(n,%) | LSIL(n,%) | HSIL(n,%) | CA(n,%) | HSIL+(n,%) | HSIL+ OR(95% CI) | |
| HPV infection(s) with 16 and/or 18 | |||||||
| HPV16 | 1047 | 522 (49.86) | 169 (16.14) | 325 (31.04) | 31 (2.96) | 356 (34.00) | |
| HPV18 | 270 | 175 (64.81) | 61 (22.59) | 30 (11.11) | 4 (1.48) | 34 (12.59) | |
| 16 + other(s)a | 492 | 213 (43.29) | 105 (21.34) | 166 (33.74) | 8 (1.63) | 174 (35.37) | |
| 18 + other(s)a | 120 | 56 (46.67) | 38 (31.67) | 26 (21.67) | 0 (0.00) | 26 (21.67) | |
| 16 + 18 + other(s) a | 79 | 30 (37.97) | 17 (21.52) | 31 (39.24) | 1 (1.27) | 32 (40.51) | |
| No. of hr HPV type(s) without HPV16 or 18 | |||||||
| 1 typeb | 839 | 558 (66.51) | 178 (21.22) | 101 (12.04) | 2 (0.24) | 103 (12.28) | 1 |
| 2 typesc | 192 | 118 (61.46) | 35 (18.23) | 39 (20.31) | 0 (0.00) | 39 (20.31) | 1.821 (1.212–2.738) |
| ≥ 3 typesd | 40 | 19 (47.50) | 6 (15.00) | 15 (37.50) | 0 (0.00) | 15 (37.50) | 4.287 (2.188–8.400) |
| Unknown type(s) | |||||||
| HC2e | 1548 | 984 (63.57) | 300 (19.38) | 247 (15.96) | 17 (1.10) | 264 (17.05) | |
| 12 hr-HPVf | 1253 | 851 (67.92) | 246 (19.63) | 156 (12.45) | 0 (0.00) | 156 (12.45) | |
| Total | |||||||
| Ng | 5880 | 3526 (59.97) | 1155 (19.64) | 1136 (19.32) | 63 (1.07) | 1199 (20.39) | |
HPV human papillomavirus
hr-HPV high-risk human papillomavirus
LSIL low-grade squamous intraepithelial lesion
HSIL high-grade squamous intraepithelial lesion
CA cervical cancer
HSIL+ high-grade squamous intraepithelial lesion or worse
OR odds ratio
CI confidence interval
a=hr-HPV genotypes except HPV16 or 18
b= single hr-HPV infection without HPV16 or 18
c= double hr-HPV infections HPV16 or 18
d= triple or more hr-HPV infections HPV16 or 18
e= infection(s) with a pool of 12 other hr-HPV types (including HPV 31,33,35,39,45,51,52,56,58,59,66 and 68) that did not know the specific type of HPV (from Cobas 4800 HPV test)
f=13 hr-HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68) tested by Hybrid Capture 2(HC2)High-Risk HPV DNA Test
g=The total number of people with hr-HPV positive in the corresponding histological results groups