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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Nitric Oxide. 2019 Dec 20;95:29–44. doi: 10.1016/j.niox.2019.12.002

Figure 5. Effect of nitrite on hypotensive response to intravenous infusion of nitrosoglutathione (GSNO) in anesthetized one-day-old lambs.

Figure 5.

An intravenous bolus of sodium nitrite to achieve ~2 μM in the blood, which alone does not cause vasodilation [50,165], resulted in a significant potentiation of the hypotensive response to GSNO compared to lambs that received a saline bolus instead of nitrite. These results are consistent with previous observations in adult sheep and rats [164]. (P < 0.05 for nitrite vs controls, 2-way ANOVA with Dunnett’s post hoc test.)