Table 1.
Cohort characteristics.
| Clinical Variables | Control (n = 426) |
COPD (n = 478) |
PRISm (n = 92) |
Missing Spirometry (n = 12) |
Whole Cohort (n = 1008) |
|---|---|---|---|---|---|
| Sex, % women | 53.3 | 42.7 | 63 | 50 | 49.1 |
| Race, % white | 88.9 | 94.8 | 91.3 | 100 | 92.1 |
| Former Smoker, % | 73.7 | 77.6 | 70.7 | 66.7 | 75.2 |
| Age (yr) | 64.6 (58.3–71.5) | 71.1 (64.9–76.6) | 67.3 (60.9–72.9) | 72 (68.2–75.3) | 68 (61–74.6) |
| Body mass index (kg/m2) | 28.4 (25.3–32.1) | 27.4 (23.7–31.7) | 30.8 (27.4–37.4) | 27.8 (25.2–30.2) | 28.1 (24.7–32.2) |
| Heart disease comorbidity (%) | 30.3 | 50.2 | 38 | 50 | 40.7 |
| FEV1% predicted | 106.8 (11.7) | 58(23.5) | 70 (7.7) | NA | 77.4 (26.6) * |
| Percent emphysema (% LAA < −950 HU) |
2.2 (2.6) | 12.8 (12.3) | 1.5 (2.6) | 9.2 (11.7) | 7.1 (10.1) ** |
Data is presented as the median (interquartile range) for age and body mass index and mean (standard deviation) for FEV1% predicted and percent emphysema. The whole cohort is the combination of former and current smokers. PRISm: Preserved Ratio Impaired Spirometry defines individuals with a reduced FEV1 but with a preserved FEV1/FVC where FVC is forced vital capacity. GOLD: the global Obstructive Lung Disease system for grading COPD severity: GOLD 1 is early COPD, GOLD 2 is moderate COPD, GOLD 3 is severe COPD, GOLD 4 is very severe COPD, and GOLD 0 is an individual without COPD. Heart disease definition can be found in the Methods section. FEV1%: percent predicted forced expiratory volume in one second. Percent emphysema: percent of lung voxels less than −950 Hounsfield Units on inspiratory CT scans. * In total, 12 subjects were removed because they did not have FEV1 values. ** In total, 60 subjects were removed because they did not have percent emphysema values (12 control, 44 COPD, and 4 PRISm).