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[Preprint]. 2020 May 13:2020.05.09.20096511. [Version 1] doi: 10.1101/2020.05.09.20096511

Figure 4. (A and B) ACE2 and related proteases expression in proximal cells.

Figure 4.

Dot plot showing the expression of proteases in DKD (in red) and LD (in blue) PTEC. Grey color denotes moderate expression (which in the was cell the by size the is dot of cells expressing gene. in Proteases were grouped into two based on the overall expression pattern in proximal cells (expression in < or >= 30% of the cells) Panel A depicts moderate (<30% of cells) and panel B widely (>=30% of cells) expressed proteases with maximal expression of ACE2 and ANPEP in DKD compared to living donor in contrast to FURIN, TMPRSS2, BSG, CTSL, DPP4 and ENPEP with higher expression in LD.

(C-G) Clinical Associations of ACE expression in proximal tubular epithelial cells in DKD.

Proximal Tubular expression of ACE2 in Female vs. Male (C) correlation with Age (D), and in relationship to exposure to any Renin-Angiotensin-Aldosterone-System Blockers (E); Angiotensin Receptor Blockers (F); Angiotensin Converting Enzyme Inhibitors(G).