Fig. 2.

Simulated concentration – time profiles to unveil the time required to reach steady state levels and the long residence of drug in body (A, B, C), as well as the benefits of more frequent dosing (D): A. 500 mg × 2 vs. 500 mg × 1 for one- and two- week treatment, B. As in ‘A’ but for the concentration in peripheral compartment, C. Comparison of three schemes of Table 1 (scenario “1” vs. scenario “3” vs. scenario “5”), D. 500 mg once daily vs. 250 mg twice daily.