Table 1.

Chloroquine dosage regimens currently in use. Dosing scenarios indicated by an asterisk (*) were explored in simulations.

No	Dosing scheme	Indication	Reference
1*	Adults: 500 mg × 2 for no more than 10 days	COVID-19	Wong et al., 2020
2	Adults: 500 mg × 2 for no more than 7 days A lower dose for patients weighing less than 50 kg	COVID-19	Wong et al., 2020
3*	Adults: At first 1000 mg once a day, then 500 mg 6 to 8 h after the first dose and then 500 mg on the second and third day of treatment Children and adults with low body weight: At first 10 mg/kg, then 5 mg/kg taken 6 h, 24 h, and 36 h after the first dose	Malaria	Mayo Clinic, 2020
4*	Adults: 1000 mg once a day taken for 2 days. This is followed by 500 mg once a day for at least 2 to 3 weeks	Treatment of liver infection caused by protozoa	Mayo Clinic, 2020
5*	Adults, including pregnant women, and children: Total dose 25 mg/kg given over 3 days as follows: Day 1: 10 mg/kg, followed by 5 mg/kg 6–8 h later [this is equivalent for a 70 kg adult to: (700 + 350)*1.613 = 1,693 mg for the first day] Days 2 and 3: 5 mg/kg in a single dose [i.e. 350 mg for a 70Kg adult] (Since, dosages above are described in terms of chloroquine base, a conversion factor of 1.613 is used for converting to chloroquine phosphate)	Parasitic diseases	WHO, 2020
6*	500 mg daily for 2–10 days. It is also suggested the potential of a loading dose of 1 g	COVID-19	Avdic, 2020
7	Treatment: 1000 mg once, then 500 mg at 6 h, 24 h and 48 h Prophylaxis (in chloroquine-sensitive regions): 500 mg (300 mg base) starting one week prior to entry, continue once weekly and then four weeks after leaving the endemic region	Malaria	Avdic, 2020
8	Days 1 and 2: 1000 mg/daily, From Day 3: 500 mg for 12 days	COVID-19	Cortegiani et al., 2020
9	150 mg chloroquine phosphate every 12 h, inhaled by atomization for one week	COVID-19	Cortegiani et al., 2020
10	Two tablets chloroquine twice daily	Mild and common COVID-19 pneumonia	Cortegiani et al., 2020
11	Two tablets chloroquine phosphate twice daily	Critically ill COVID-19 pneumonia	Cortegiani et al., 2020
12	12.600 mg twice daily for 10 days versus 450 mg twice daily (Day 1) followed by 450 mg once daily, for 4 days	Critically ill COVID-19 pneumonia	Borba et al., 2020