Figure 1.

Experiment Scheme and Body-Weight Changes in SARS-CoV-2-Infected HFH4-hACE2 Mice

(A) Twenty-four HFH4-hACE2 mice were intranasally infected with 3 × 10⁴ TCID₅₀ virus each and sacrificed to collect tissue and blood samples at 1, 3, 5, and 7 days post-infection (DPI). Mouse body weights were monitored for up to 7 days. Each dot represents one mouse at the indicated time point. One mouse showed a rapid body weight decrease with dyspnea beginning on day 2 and then recovered (green dot). Infected mice that died showed noticeable body weight decreases from day 4 to 6 (red dot).

(B) Mock-infected (blue dot) and survived mice (black dot) demonstrated normal statuses. The dotted lines represent the fitted curve of each color-indicated group.

See also Figure S1 and Tables S1 and S2.