Figure 4.

Experiment Scheme and Mortality of HFH4-hACE2 Mice after SARS-CoV-2 Infection

Six hACE2 mice (four males and two females) were intranasally infected with 3 × 10⁴ TCID₅₀ SARS-CoV-2. Body weights and survival were monitored. Three survived mice were observed at 21 days. Then, the three surviving mice and another three healthy mice were intranasally infected with 7 × 10⁵ TCID₅₀ SARS-CoV-2.

(A) The number in the parenthesis indicates the DPI of reinfection.

(B) Body weights and survival were monitored every day. Body weights decreased quickly, beginning at 4 DPI and led to death, or mice survived in the absence of significant body weight decreases.

(C) Three of four male mice died after infection, while two females survived.

Error bars indicate the standard error.

See also Table S4.