Table 3.
Comparison table of clinical characteristics between Q703K-positive vs. -negative CAPS patients.
| Q703K+ (n: 6) | Q703K- (n: 20) | P-value | |
|---|---|---|---|
| Median age at onset (years.months) | 0.7 | 0.1 | |
| Median age at diagnosis | 6.9 | 4.1 | |
| Sex ratio (M/F) | 2/1 | 2/1 | 1 |
| Positive familial history* | 1/4 | 9/16 | 0.5820 |
| Recurrent Fever | 3 | 4 | 0.2929 |
| Pharyngitis | 2 | 0 | 0.0462 |
| Abdominal pain | 1 | 2 | 1 |
| Neurologic symptoms | 2 | 7 | 1 |
| Adenopathy | 1 | 4 | 1 |
| Urticaria | 4 | 17 | 0.5581 |
| Headache | 3 | 2 | 0.0624 |
| Myalgia | 1 | 2 | 1 |
| Arthralgia | 4 | 12 | 1 |
| Rash | 1 | 1 | 0.4154 |
| Diarrhea | 1 | 0 | 0.2308 |
| Conjunctivitis | 2 | 5 | 1 |
| Oral aphthosis | 1 | 0 | 0.2308 |
| Hearing loss | 2 | 5 | 1 |
| Disease Complications** | 1 | 6 | 1 |
| FCAS | 3 | 4 | 0.2929 |
| MWS | 3 | 12 | 1 |
| CINCA/NOMID | 0 | 4 | 0.5425 |
*
familial History is available in only 4 Q703K-positive and 16 negative CAPS patients.
**
disease complications include ocular complications, renal insufficiency, skeletal and joint deformities, growth and neurodevelopmental delay.