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. Author manuscript; available in PMC: 2020 May 21.
Published in final edited form as: AAPS J. 2019 Sep 3;21(6):103. doi: 10.1208/s12248-019-0373-3

Table II.

Ratios of midazolam blood pharmacokinetic parameters with/without 7 days of clarithromycin dosing

IV Midazolam Ratios Parameter Oral Midazolam Ratios
2.7 AUC 7.1
1.3 Cmax 3.3
0.37 CL CL/F
F, FH, FG 		0.14
2.4, 1.2, 2.0
1.1
1.0		 Vss Vss/F
V1 		0.35
2.7 t½terminal 2.6
3.0 MRT 2.5

AUC, CL, F and t1/2terminal values as reported by Gorski et al. (12) using weight corrected values for AUC and CL; Cmax, Vss, V1 and MRT determined from digitized data from figures of average concentration time curves.