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. Author manuscript; available in PMC: 2020 May 21.
Published in final edited form as: ACS Infect Dis. 2019 Jun 11;5(8):1433–1445. doi: 10.1021/acsinfecdis.9b00112

Figure 1.

Figure 1.

A whole cell screen resulted in the identification of 86 β-lactams active under NR conditions. (A) Analysis of Table S1 according to compound activity under replicating (R) or nonreplicating (NR) conditions with or without 0.5 mM NaNO2 and with a starting inoculum of 0.1 or 0.01. Seven compounds were active only under NR conditions with NaNO2 and low inoculum. (B) Stability of 70 out of the 86 active compounds in mouse plasma. Compound 1a is represented as a broken red line (− .. −); compound 3 is represented as a dotted red line (…). This large-scale experiment was conducted once. (C) Structure and MIC90 values of selected compounds. (D) Stability in human or marmoset plasma after a 60 min incubation at 37 °C of the dual-active compounds selected for further studies.