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. Author manuscript; available in PMC: 2020 May 21.
Published in final edited form as: ACS Infect Dis. 2019 Jun 11;5(8):1433–1445. doi: 10.1021/acsinfecdis.9b00112

Figure 3.

Figure 3.

Studies of the mode of action of the PYR containing-cephalosporins. (A) Hypothetical release of PYR from the cephalosporin backbone following β-lactamase cleavage. (B−D) CARAs were used to compare the activity profile of 1a, 4, and PYR under R conditions and NR conditions with and without nitrite. (E, F) CFU/mL reduction over time when cells are exposed to 1.5× CARAMBC concentrations of the 1a and PYR sodium salt under R and NR conditions as compared to rifampicin under R conditions or 4 under NR conditions. Results are means ± SD of triplicates. Experiments were conducted at least twice.