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. Author manuscript; available in PMC: 2020 May 21.
Published in final edited form as: ACS Infect Dis. 2019 Jun 11;5(8):1433–1445. doi: 10.1021/acsinfecdis.9b00112

Figure 6.

Figure 6.

Role of BlaC in PYR release. (A) Estimated levels of PYR recovered after incubating with 1 μM BlaC for 10 min represented as the percent of the initial concentration of parent compound. (B) The absorption spectrum of 100 μM of cephalothin and 1a before and after 10 min of incubation with 1 μM BlaC. (C) The efficacy of PYR and 1a in M. tuberculosis WT (open circles), BlaC KO (PM638, squares), and complemented strain (PM669, triangles). (D) The efficacy of clavulanate dependent 3 in M. tuberculosis WT (open circles), BlaC KO (PM638, squares), and complemented strain (PM669, triangles). Results are means ± SD of triplicates