Table 8.

HA-based biomaterials in bone regeneration

No.	Composite	Method of preparation	Advantages	Disadvantages
1	HA-Chitosan	In situ chemical synthesis, freeze drying, co-precipitation	Pore forming ability, good binding capacity, anti-bacterial and biodegradable	Mechanical properties need to be improved [122–134]
2	HA-Collagen	Supercritical fluid assisted process, cryogelation technique	Better cell attachment, proliferation and differentiation ability	Presence of charged and polar groups which critically affect the nucleation of the HA crystals on collagen membrane through chemical interaction [136–153]
3	HA-Polycaprolactone (HA/PLC)	Modified rapid-prototyping for nHA/PLC, pressure quench nHA/PLC	Good biodegradation, mechanical strength, growth of MSCs and guide their osteogenic differentiation.	Difficulty in new bone tissue binding [2,152–167]
4	HA-Polyvinyl alcohol	Freeze/thaw, spray drying	Good hydrophilicity, excellent chemical stability, useful for bone tissue engineering and articular cartilage repair.	Need further in vitro and in vivo studies [8,9,168–177]
5	HA-Poly(lactic-co-glycolic) acid	Selective laser sintering, Electrospinning	Good compressive strength and modulus of elasticity	Smaller pore size [178–182]