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. 2020 May 4;40(1):162–168. doi: 10.1080/01652176.2020.1758357

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic representation of filaggrin (FLG) metabolism. ProFLG, the FLG precursor, is stored in keratohyalin granules in the stratum granulosum keratinocytes. ProFLG is released in the cytoplasm in response to increased Ca²⁺ levels, then it is dephosphorylated and cleaved by not well-characterized proteases leading to the production of FLG monomers. The monomers aggregate keratin intermediate filaments and induce collapse and flattening of corneocytes. Finally, FLG is deiminated and degraded in the upper stratum corneum to natural moisturizing factor components. Abbreviations: SG, stratum granulosum; SC, stratum corneum; proFLG, profilaggrin; FLG, filaggrin. Adapted from Nishifuji and Yoon (2013).