Table 2.

The IC₅₀ (µM) of the synthesised compounds (7–21) against tested human cancer cell line (MCF-7 and HCT-116)^a.

Compound	MCF-7b	HCT-116c
7	53.50	57.34
8	56.0	56.76
9	7.74	12.84
10	7.87	16.14
11	58.37	68.13
12	56.28	58.64
13	56.3	58.64
14	43.37	42.21
15	47.8	39.60
16	58.4	67.10
17	65.17	55.5
18	>100	>100
19	61.6	69.50
20	>100	>100
21	61.95	63.15
5-FUd	34.82	40.51

^aIC₅₀ values are the concentrations that cause 50% inhibition of cancer cell growth. Data represent the mean values ± standard deviation of three independent experiments performed in triplicate.

^bBreast cancer (MCF-7); colorectal cancer (HCT-116).

^c5-FU: 5-florouracil was used as a reference drug (positive control).

Bold values: significant cytotoxicity compared to standard drug 5-FU.