Table 3.
In vitro thymidylate synthase (TS) activity of the active compounds 9, 10, 14, 15 and PTX.
| Compounds | IC50 (µM) |
|---|---|
| 9 | 1.67 |
| 10 | 2.21 |
| 14 | 9.4 |
| 15 | 7.9 |
| PTX | 8.2 |
IC50 values are the mean ± SD of three separate experiments. PTX: Pemetrexed.
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