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. 2020 Apr 29;27(1):652–661. doi: 10.1080/10717544.2020.1756984

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (a) The process of interaction between Mt-BH-SLNs and mucin in ocular tear film. Tear film was composed of lipid layer, aqueous layer and mucin layer. Mt-BH-SLNs with opposite charge to mucin bind to it by electrostatic interaction. The hydrophilicity of Mt-BH-SLNs surface was improved due to the release of water-soluble BH to the nanoparticles surface. Mt-BH-SLNs with increased surface hydrophilicity could penetrate or dissolve in aqueous mucus, and ocular surface retention time could be prolonged; (b) Concentration of BH in rabbit aqueous humor at various time points after instillation of different formulations; (c) The microdialysis sampling technique of rabbit eye; (d) The pharmacological response (the decrease in IOP, △IOP) versus time profiles for BH solution and Mt-BH-SLNs; (e) The schematic drawing of IOP, which caused by blocked aqueous circulation and further damaged the optic nerve head.