Table 2.
Enzymatic activities of compound 7d against FLT3 mutants.
| Kinase | IC50 (µM) |
|---|---|
| FLT3 (F594_R595 ins R) | 0.524 |
| FLT3 (F594_R595 ins EY) | 0.495 |
| FLT3 (Y591_V592 ins VDFREYEYD) | 0.728 |
| FLT3 (D835Y) | 0.228 |
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